Check out the many health advantages of konjac food like konjac rice if you want to lose weight, get healthier, or just make general dietary improvements. In fact, studies suggest that eating this kind of food may help prevent cancer and other serious illnesses like diabetes and heart disease.
During aging, a variety of processes take place, from structural remodeling to cellular changes. These changes are correlated with decreased respiratory function and reduced metabolic flexibility. While the effects of ageing can vary from tissue to tissue, they can also affect the health of the entire organism. These changes can be quantified through metabolomics keto diet healthy, a technique that uses NMR spectroscopy to identify metabolite signatures. These signatures can be used as markers for a variety of age-related disorders.
The O-PLS-DA score plot allowed a thorough discrimination between young and old mice. The HSQC spectrum confirmed the findings. The olfactory function of a young blood sample was improved. This is not surprising considering the fact that the heart is a complex organ.
Aside from the obvious structural changes, an ageing mouse's heart exhibited some pretty interesting metabolite changes. The most notable was a boost in the concentration of aromatic amino acids. Another was a decreased concentration of fumarate. Interestingly, all three branched-chain amino acids (BCAAs) were increased in old mice. In contrast, malonate was decreased.
The effects of konjac meal like konjac noodles on the aging of the brain, liver, and cardiovascular tissues have been examined in a number of studies. The most significant impact was on the AMP-activated protein kinase (AMPK) pathway, which controls inflammation and glucose homeostasis. Additionally, AMPK is crucial for the management of long-term metabolic diseases.
In mice given a high-fat diet, the impact of KMOS on lipid and glucose metabolism was investigated (HFD). While the effects on insulin tolerance were strengthened in the HFD-HFD group, the HOMA-IR index was significantly attenuated in the HFD-KMOS and H-KMOS groups. Additionally, dietary pectin's effects on hepatic triglyceride content, monovalent minerals, heavy metals, and bivalent mineral absorption were investigated.
The findings demonstrated that liver triglyceride metabolism abnormalities were corrected by KMOS supplementation. Additionally, it reversed the abnormalities in glucose uptake and insulin tolerance in the mice fed the HFD. The mechanisms underlying KMOS's hypoglycemic effect are still unknown, though.
Glucomannan (also known as konjac mannan) has been linked to reduced post-prandial glycaemic responses and normal blood cholesterol concentrations. These proper intioxidative defences. In this review, the relevant toxicological studies are summarized.
To evaluate the antioxidant activity of glucomannan, researchers studied oxidative stress-related enzymes, antioxidant enzymes, and antioxidant defenses. The antioxidant response was modeled using a meta-regression model. It was found that the magnitude of the antioxidant response was dependent on a number of factors. These included species, biological matrix, and age. The results revealed that 5-oxoproline was effective in reducing total radical-trapping antioxidant potential, total antioxidant reactivity, and thiobarbituric acid-reactive substances. It also decreased sulfhydryl content.
A more comprehensive study examined the antioxidant effects of glucomannan like glucomannan noodles against deoxynivalenol, an organic mycotoxin. Deoxynivalenol induces apoptosis and cell-cycle arrest. It inhibits DNA repair and increases peroxidation. It was evaluated in a human hepatoma cell line and in RAW 264.7 macrophages. It was also tested against leontopodic acid and against aflatoxin B1.
In another study, a reversible inhibition of T-2 toxin-induced lipid oxidation was observed in a chicken liver model. Moreover, l-carnitine protected rat hepatocytes from T-2 toxin-induced oxidative stress. This was mediated by the NRF2 pathway, which maintains cellular redox homeostasis. In addition, Se, a redox-inhibitory compound, prevented abnormal caspase-3 activity. It also promoted protein synthesis and ameliorated oxidative stress and lipid peroxidation.
A useful tool for ensuring the safety and quality of food is the ability to identify the presence of konjac glucomannan using ELISA. Additionally, this kind of detection can offer a way to spot dietary adulteration, like the addition of additional gums.
Numerous investigations have been done to gauge glucomannan's effects. They discovered that it prevents IgE class switching, lessens water-soluble vitamin B12 absorption, boosts glutalase gene expression in the colon, and strengthens antioxidant defense mechanisms. Additionally, it prevents the growth of liver nodules.
A study by Doi et al. (1998) also looked into the effects of konjac calorie glucomannan on metabolism and nutrition. They examined the impact of glucomannan feeding on liver enzymes, faecal SCFA, and serum cholesterol. Low-density lipoprotein cholesterol was reduced by 7.2% and total cholesterol by 10% by the glucomannan fibers. High-density lipoprotein cholesterol, diastolic blood pressure, or body weight did not alter.
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We offer one-stop services from raw materials to finished products, covering 33 million square meters of base konjac.
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